Hydroxychloroquine official statements, trials and studies

07/09/2020

Analysis of the predictive factors for critical illness of COVID-19 during treatment – Relationship between serum zinc level and critical illness of COVID-19

Source: Science Direct Author links YukakoYasuiaHiroyukiYasuibKumikoSuzukicTakakoSaitoucYoshikiYamamotoaToshihikoIshizakaaKoujiNishidadShingoYoshiharaeIwaoGohmadYoshihikoOgawae aDepartment of Pharmacy, Sakai City Medical Center, 1-1-1 Ebaraji-cho, Nishi-ku, Sakai City, Osaka, 593-8304, Japan bDepartment of Analytical & …

07/09/2020

06/09/2020

C19study.com update: Now 88 international studies (51 peer reviewed) show positive hydroxychloroquine treatment outcomes

Source: c19 Study A live and ongoing index of study data from around the world documenting the use of hydroxychloroquine in treatment at various stages …

06/09/2020

04/09/2020

Hydroxychloroquine is Effective and Safe for the Treatment of COVID-19, and May be Universally Effective When Used Early Before Hospitalization: A Systematic Review

Source: Research Gate Conclusions Hydroxychloroquine has been shown to have consistent clinical efficacy for COVID-19 when it is used early in the outpatient setting, and …

04/09/2020

03/09/2020

Indian Medical Association endorses prophylactic HCQ use for police force

Source: Steven Phillips, MD Indian Medical Association endorses prophylactic use of HCQ for the police department to prevent COVID19. The Bengal State Branch recommended to …

03/09/2020

02/09/2020

COVID-19 mortality risk factors in older people in a long-term care center

It could be possible that this treatment only works when used early and in particular patient groups with similar characteristics as in the present study.

02/09/2020

01/09/2020

FRANCE: EFFECT OF HYDROXYCHLOROQUINE WITH OR WITHOUT AZITHROMYCIN ON THE MORTALITY OF COVID-19 PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

We believe this study is fatally flawed: “Effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients: a systematic review and meta-analysis”.

01/09/2020

01/09/2020

Spain – 1766P COVID-19 and lung cancer: What do we know?

There seems to be a trend towards lower mortality among patients who received treatment with the combination of hydroxychloroquine and azithromycin than among those who did not

01/09/2020

31/08/2020

Study to commence: Hydroxychloroquine plus personal protective equipment versus standard personal protective equipment alone for the prevention of COVID-19 infections among frontline healthcare workers: the Hydroxychloroquine Prophylaxis Evaluation(HOPE) trial: A structured summary of a study protocol for a randomized controlled trial

This is an Indian study about the use of hydroxychloroquine for infection prevention against COVID-19. This study has not released any official data yet.

31/08/2020

27/08/2020

COVID-19 and rheumatic autoimmune systemic diseases: report of a large Italian patients series

Hydroxychloroquine may interfere with viral infection or cytokine storms observed in Covid-19 with severe acute respiratory distress syndrome.

27/08/2020

27/08/2020

Panama’s Ministry of Health: Covid-19 death toll decreased due to hydroxychloroquine use

Source: Panama’s Minitry of Health Since the Ministry of Health authorised the use of Hydroxychloroquine and / or Azithromycin as drugs to treat COVID-19 positive …

27/08/2020

26/08/2020

Hydroxychloroquine and azithromycin tolerance in haemodialysis patients during COVID-19 infection

HCQ and AZI are safe in haemodialysis patients at these doses, and HCQ concentrations were not correlated with side effects.

26/08/2020

25/08/2020

New Jersey Study of 1,274: Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19; A multi-center observational study where hydroxychloroquine exposure was associated with a decreased rate of subsequent hospitalization

In this study, SARS-CoV-2 infected non-hospitalized patients hydroxychloroquine exposure was associated with a decreased rate of subsequent hospitalization.

25/08/2020

25/08/2020

Italy Study 3,451 patients: Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study

HCQ use was associated with a 30% lower risk of death in COVID-19 hospitalized patients. Our data doesn’t discourage use of HCQ in inpatients with COVID-19.

25/08/2020

25/08/2020

Scholz, Derwand, Zelenko COVID-19 HCQ study, explained

Source: Murray Wiseman Authors: Scholz, Derwand, Zelenko A discussion of a retrospective study early risk-stratified treatment of Covid-19 outpatients with zinc plus low-dose hydroxychloroquine and …

25/08/2020

24/08/2020

Belgium Study: Low-dose Hydroxychloroquine Therapy and Mortality (Lowered) in Hospitalized Patients with COVID-19: A Nationwide Observational Study of 8075 Participants

Source: Science Direct Authors: LucyCatteauPharmD, PhDafi#NicolasDaubyMD, PhDbcdfi#MarionMontourcyMScafiEmmanuelBottieauMD, PhDefiJorisHautekietMScagfiElsGoetghebeurPhDfigSabrinavan IersselMD, PhDfihElsDuysburghMD, MPH, PhDafiHermanVan OyenMD, DrPHafhiChloéWyndham-ThomasMD, PhDafiDominiqueVan BeckhovenMD, MScafiBelgian Collaborative Group on COVID-19 hospital surveillance aEpidemiology and …

24/08/2020

21/08/2020

Australia: Clinical trial looks to protect high-risk healthcare workers against COVID-19 using hydroxychloroquine as preventative to corona

Source: St Vincent’s Hospital Melbourne Healthcare workers are part of the first line of defence in today’s fight against COVID-19. But as this global virus …

21/08/2020

20/08/2020

Mortality 0%: A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: results of a retrospective observational study in the French overseas department of Reunion Island

Indeed, following bivariate analysis, hydroxychloroquine/azithromycin treatment was associated with a lower rate of ICU admission (P=0.008).

20/08/2020

20/08/2020

Pattern of SARS-CoV-2 infection among dependant elderly residents living in retirement homes in Marseille, France, March-June 2020.

This data states that early care of COVID-19 patients at retirement homes can be effective in saving lives when treated with hydroxychloroquine.

20/08/2020

19/08/2020

Hydroxychloroquine, Parachutes And How to Understand ‘The Evidence’

What If a person advocated that parachutes don’t work, we should ban usage and pilots who give a parachute to skydivers should lose their pilot’s license

19/08/2020

18/08/2020

US Senators request HCQ decision information from FDA’s Stephen Hahn

Source: US Senate Authors: Ron Johnson, Mike Lee, Ted Cruz WASHINGTON, DC 20510 August 18, 2020 The Honorable Stephen Hahn Commissioner U.S. Food and Drug …

18/08/2020

17/08/2020

Hydroxychloroquine Safety Outcome within Approved Therapeutic Protocol for COVID-19 Outpatients in Saudi Arabia

Hydroxychloroquine for COVID patients in moderate cases within the recommendation and use criteria, is safe, highly tolerable, and with little side effects.

17/08/2020

11/08/2020

The effect of 5-day course of hydroxychloroquine and azithromycin combination on QT interval in non-ICU COVID19(+) patients

The 5-day course of HCQ -AZM combination did not lead to significant QT prolongation and other conduction delays compared to baseline ECG in non-ICU COVID19(+) patients.

11/08/2020

11/08/2020

Hydroxychloroquine Case Is Filed in the Sixth Circuit by AAPS

Source: AAPS Online On Monday the Association of American Physicians & Surgeons filed its Petition for Writ of Mandamus with the U.S. Court of Appeals for the …

11/08/2020

03/08/2020

China Study of 2882 patients: Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs

HCQ treatment can reduce systemic inflammation and inhibit the cytokine storm, thus protecting multiple organs from inflammatory injuries.

03/08/2020

03/08/2020

Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?

The evidence shown in this work let us think that Zn(II) indeed may play a role in the viral cell cycle, and zinc ionophores boost zinc’s effects.

03/08/2020

02/08/2020

France Study: Impact of medical care including anti-infective agents use on the prognosis of COVID-19 hospitalized patients over time

Indeed, our study suggests that AZI±HCQ might have impacted COVID-19 outcome in a population of patients, optimal timing of treatment interventions to study

02/08/2020

02/08/2020

A New Model of SARS-CoV-2 Infection Based on (Hydroxy) Chloroquine Activity

The metabolic inhibitors determine which pathways actively inhibits mitochondrial ATP production with hydroxychloroquine

02/08/2020

30/07/2020

Hydroxychloroquine might be the most effective in reducing the duration of Covid-19 symptoms: BMJ living systematic review and network meta-analysis

Under ‘Time to resolution of symptoms’ in this article’s interactive diagram, it states that out of the studies referenced, “Hydroxychloroquine might be the most effective in …

30/07/2020

29/07/2020

Italy Study: Effectiveness of Hydroxychloroquine in COVID-19 disease: A done and dusted situation? – 66% reduction in risk of death

hydroxycholoroquine + azithromycin was associated with a 66% reduction in risk of death as compared to controls; the analysis also suggested a larger effectiveness of hydroxychloroquine in patients with less severe COVID-19 disease

29/07/2020

29/07/2020

Kentucky Board of Pharmacy repeals restrictions on hydroxychloroquine prescriptions

Source: Kentucky Board of Pharmacy KENTUCKY BOARD OF PHARMACYDirectives revised July 29, 2020 The directive placing restrictions on prescriptions for chloroquine, hydroxychloroquine, mefloquine, or azithromycin …

29/07/2020

28/07/2020

FDA Delays on HCQ Outpatient Approval Are Causing Deaths Daily

Dr. Hahn’s FDA is costing more lives with its delay in removing the obstructions it created to prescribing safe, effective early HCQ treatment

28/07/2020

23/07/2020

61 studies (37 peer reviewed) Early treatment studies are very positive – COVID deaths: 621, 206

Source: c19study.com The studies continue to roll out, and there has been very positive results in pre and post exposure as well as early treatment …

23/07/2020

17/07/2020

Madrid Study: Observational Study of the Efficiency of Treatments in Patients Hospitalized with Covid-19 in Madrid – Risk of death significantly lower with HCQ

Source: Medrxiv.org In this analysis of 1645 patients hospitalized with COVID-19 we find that the risk of death was significantly lower for patients treated with …

17/07/2020

16/07/2020

South Korea Study: Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory Syndrome Coronavirus 2 Eradication

Source: IC Journal Citation: Hong KS, Jang JG, Hur J, Lee JH, Kim HN, Lee W, Ahn JH.   Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory …

16/07/2020

14/07/2020

Oregon Pharmacy Board repeals rule that restricted use of HCQ for COVID-19 infection to patients enrolled in a clinical trial.

SOURCE: Oregon Secretary of State The Oregon Secretary of State posted an amendment that officially lifts the Pharmacy Board’s rule that restricted use of HCQ …

14/07/2020

12/07/2020

UK Study: Mortality, causes of death and influence of medication use in patients with systemic lupus erythematosus vs matched controls

HCQ use significantly reduced the mortality rate, but this association was found only in the lowest cumulative dosage exposure group.

12/07/2020

06/07/2020

C19 Study: 53 studies (31 peer reviewed) showing “very positive” results using HCQ as pre & post exposure prophylaxis & early treatment.

Source: c19 Study A live and ongoing index of study data from around the world documenting the use of hydroxychloroquine in treatment at various stages …

06/07/2020

02/07/2020

Treatment with Hydroxychloroquine Cut Death Rate Significantly in COVID-19 Patients, Henry Ford Health System Study Shows

Source: Henry Ford Health System DETROIT – Treatment with hydroxychloroquine cut the death rate significantly in sick patients hospitalized with COVID-19 – and without heart-related side-effects, …

02/07/2020

01/07/2020

HENRY FORD STUDY: Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19

Source: International Journal of Infectious Diseases Highlights As of May27, 2020 there are over 1,678,843 confirmed cases of COVID-19 claiming more than 100,000 lives in …

01/07/2020

30/06/2020

NY Study: Risk Factors for Mortality in Patients with COVID-19 in New York City

In this study of over 6000 hospitalized patients with COVID-19 in the New York City, hydroxychloroquine use was associated with decreased mortality.

30/06/2020

30/06/2020

Risk Factors for Mortality in Patients with COVID-19 in New York City

Hydroxychloroquine use was associated with decreased mortality.

30/06/2020

29/06/2020

Chronic treatment with hydroxychloroquine and SARS-CoV-2 infection.

Our data suggest that chronic treatment with HCQ confer protection against SARS-CoV-2 infection.

29/06/2020

29/06/2020

Electrocardiographic safety of daily Hydroxychloroquine 400mg plus Azithromycin 250mg as an ambulatory treatment for COVID-19 patients in Cameroon.

No life-threatening modifications of the QT interval was observed in non-severe COVID-19 patients treated ambulatory with hydroxychloroquine and azithromycin. Studies are needed in critical-ill and older patients.

29/06/2020

26/06/2020

National Cancer Instititute: List of Active Clinical Trials Using Hydroxychloroquine for Cancer

The clinical trials on this list are studying Hydroxychloroquine. All trials on the list are supported by NCI.

26/06/2020

25/06/2020

Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/ azithromycin and other regimens in Marseille, France: A retrospective analysis

Source: Science Direct Background In our institute in Marseille, France, we initiated early and massive screening for coronavirus disease 2019 (COVID-19). Hospitalization and early treatment …

25/06/2020

22/06/2020

Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of COVID-19 Spike pseudotype virus

Source: BioRxiv The pandemic coronavirus COVID-19 affected global health from the end of 2019 to 2020 and may challenge global health in the future. There …

22/06/2020

22/06/2020

Efficacy and safety of chloroquine or hydroxychloroquine in moderate type of COVID-19: a prospective open-label randomized controlled study

This study provides evidence that (hydroxy)chloroquine may be used effectively in treating moderate COVID-19 and supports larger trials.

22/06/2020

22/06/2020

Denmark: Chloroquine, but not hydroxychloroquine, prolongs the QT interval in a primary care population

Conclusions: In subjects free of COVID-19, we found a small increase in QTc associated with use of chloroquine, but not hydroxychloroquine. We found no increased mortality associated with use of hydroxychloroquine.

22/06/2020

22/06/2020

Study|China- Efficacy and safety of chloroquine or hydroxychloroquine in moderate type of COVID-19: a prospective open-label randomized controlled study

This study provides evidence that (hydroxy)chloroquine may be used effectively in treating moderate COVID-19 and supports larger trials.

22/06/2020

19/06/2020

Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: a cohort study of 4,642 in-patients in France

Significantly higher rates of discharge home were observed in patients treated by HCQ, a novel finding warranting further confirmation in replicative studies.

19/06/2020

12/06/2020

Spain Study: A short therapeutic regimen based on hydroxychloroquine plus azithromycin for the treatment of COVID-19 in patients with non-severe disease. A strategy associated with a reduction in hospital admissions and complications.

None of the patients died in the studied period and only 6 have to be admitted in conventional hospitalization area.

12/06/2020

04/06/2020

WHO restarts Hydroxychloroquine trials globally after dubious study derailed progress – they’ve confirmed no risk of mortality

On the 25th of May 2020, the World Health Organisation halted hyrdoxychloroquine trials globally within 72 hours of sighting a publication in the Lancet. They …

04/06/2020

02/06/2020

HCQ: The Lancet announces serious scientific questions about it’s own published study, which immediately halted WHO trials around the globe

Source: The Lancet Expression of concern: Hydroxychloroquine or chloroquinewith or without a macrolide for treatment of COVID-19:a multinational registry analysis. Important scientific questions have been …

02/06/2020

02/06/2020

Association of American Physicians & Surgeons (AAPS) Sues the FDA to End Its Arbitrary Restrictions on Hydroxychloroquine

Source: AAPS Today, June 2, 2020, the Association of American Physicians & Surgeons (AAPS) filed a lawsuit, AAPS v. FDA, against the Food and Drug Administration …

02/06/2020

31/05/2020

Health Co-operation between the Governments of Brazil and the United States

Source: Brazil Ministry of Foreign Relations The Brazilian people and the North American people show solidarity in the fight against the coronavirus. Today, as a demonstration …

31/05/2020

31/05/2020

US Government delivers two million doses of hydroxychloroquine (HCQ) to the people of Brazil.

Source: The White House The American and Brazilian people stand in solidarity in the fight against the coronavirus.  Today, as a demonstration of that solidarity, …

31/05/2020

28/05/2020

Study – Viral Dynamics Matter in COVID-19 Pneumonia: the success of early treatment with hydroxychloroquine and azithromycin in Lebanon. (94.7% Success rate)

Source: Medrxiv View ORCID Profile Amanda Chamieh, Claude Afif, View ORCID Profile Gerard El-Hajj,  View ORCID Profile Omar Zmerli, Isabelle Djaffar-Jureidini,View ORCID Profile Roy A. Raad, Raja Ashou, George Juvelekian,View ORCID Profile Jean-Marc Rolain,View ORCID Profile Eid Azar doi: https://doi.org/10.1101/2020.05.28.20114835 This article …

28/05/2020

28/05/2020

EARLY DIAGNOSIS AND MANAGEMENT OF COVID-19 PATIENTS: A REAL-LIFE COHORT STUDY OF 3,737 PATIENTS, MARSEILLE, FRANCE (HCQ-AZ)

Source: Mediterranee Infection COVID-IHU #15 Version 1 du 27 Mai 2020Early diagnosis and management of COVID-19 patients: a real-life cohort study of 3,737 patients, Marseille, France Abstract Background:In our institute in Marseille, France, we …

28/05/2020

28/05/2020

182 Professionals from 25 countries around the globe raise serious concerns with The Lancet’s anti HCQ report

Source: Zendo In an open letter to MR Mehra, SS Desai, F Ruschitzka, and AN Patel, authors of “Hydroxychloroquine or chloroquine with or without a …

28/05/2020

27/05/2020

Most COVID-19 patients in Armenia show positive “dynamics” from hydroxychloroquine – ministry

Source: armenpress YEREVAN, MAY 27, ARMENPRESS. The Armenian Healthcare Ministry says the efficiency of the use of hydroxychloroquine for treating COVID-19 patients aren’t yet fully summed …

27/05/2020