Hydroxychloroquine official statements, trials and studies

26/05/2020

TANG ET AL, BMJ: Favourable data for hydroxychloroquine removed between study’s draft and final print

Source: Mediterranee Infection Why this discrepancy between the preprint version and the version published in the BMJ? Tang et al. – Data (text and figures) evidencing …

26/05/2020

24/05/2020

University of Edinburgh, Scotland, Centre for Clinical Brain Sciences finds Lancet report irrelevant

Source: Recovery Trial Professor Peter Horby, Professor Martin LandrayRECOVERY trial Co-chairsNuffield Department of Public HealthOxford24th May 2020 Dear Peter and Martin RECOVERY trial DMC Chairman’s …

24/05/2020

22/05/2020

Revised advisory on the use of Hydroxychloroquine (HCQ) as prophylaxis for SARS-CoV-2 infection

Source: Indian Council of Medical Research 1. Background The Joint Monitoring Group under the Chairmanship of DGHS and including representatives from AIIMS, ICMR, NCDC, NDMA, …

22/05/2020

21/05/2020

Study: Potential specific therapies in COVID-19 include hydroxychloroquine

Source: SagePub.com Convalescent blood products are promising potential therapies for COVID-19. Other antivirals such as chloroquine or HCQ, remdesivir, and immune modulators such as tocilizumab …

21/05/2020

19/05/2020

VA Secretary Robert Wilkie: On Any Given Day, VA Uses 42,000 Doses Of Hydroxychloroquine

Source: Real Clear Politics VA Secretary Robert Wilkie fact-checked a common misconception about the common anti-malarial drug Hydroxychloroquine after the president was asked about it …

19/05/2020

19/05/2020

FDA Bureaucrat Brags He Blocked Physician Prescribing of Hydroxychloroquine in Early COVID-19

How can one person brag about blocking physicians’ attempt to reduce hospitalization and deaths during a national emergency?

19/05/2020

19/05/2020

Trump takes hydroxychloroquine + zinc to prevent coronavirus infection as lots of evidence suggests it works

SOURCE: CNBC News President Donald Trump said Monday that he has been taking anti-malaria drug hydroxychloroquine for a couple of weeks to prevent coronavirus infection even though the media …

19/05/2020

18/05/2020

50 Science References Supporting Hydroxychloroquine: Microbiology Professor at Universidade de São Paulo, Paola Zanotto

SOURCE: Covexit.com The esteemed professor Paolo Zanotto, from the University of Sao Paulo, has released a list of 50 scientific references supporting the use of …

18/05/2020

15/05/2020

Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19

Source: Springer Coronavirus disease 2019 (COVID-19) is a pandemic with no specific drugs and high fatality. The most urgent need is to find effective treatments. …

15/05/2020

12/05/2020

Predicted success of prophylactic antiviral therapy to block or delay SARS-CoV-2 infection

Source: MedRxiv Repurposed drugs that are immediately available and have a good safety profile constitute a first line of defence against new viral infections. Despite …

12/05/2020

09/05/2020

Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients

Source: Preprints Although no specific treatment for COVID 19 has been proven effective yet, some drugs with in vitro potential against SARS-CoV-2 virus have been …

09/05/2020

08/05/2020

Hydroxychloroquine and azithromycin plus zinc vs hydroxychloroquine and azithromycin alone: outcomes in hospitalized COVID-19 patients

Source: MedRxiv Background: COVID-19 has rapidly emerged as a pandemic infection that has caused significant mortality and economic losses. Potential therapies and means of prophylaxis …

08/05/2020

08/05/2020

Peer reviewed; 91.7% good outcomes with early treatment of COVID-19 patients using hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France

Source: Science Direct Abstract Background In France, the combination hydroxychloroquine (HCQ) and azithromycin (AZ) is used in the treatment of COVID-19. Methods We retrospectively report …

08/05/2020

04/05/2020

Study of the safety and efficacy of chloroquine for the treatment of COVID-19

Source: MedRxiv Background Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has been proved to have antiviral effect against coronavirus in vitro. In …

04/05/2020

02/05/2020

Yale’s COVID-19 inpatient official protocol: Hydroxychloroquine plus/minus tocilizumab

Source: MDedge | Hematology& Oncology Hydroxychloroquine is currently first-line, and tocilizumab second-line, for people hospitalized with polymerase chain reaction–confirmed COVID-19 in the Yale New Haven …

02/05/2020

01/05/2020

China study of 568 critically ill Covid-19 patients: Hydroxychloroquine treatment significantly associated with a decreased mortality, through attenuation of inflammatory cytokine storm.

Source: MedRxiv Abstract Importance: Coronavirus disease 2019 (COVID-19) is a pandemic with no specific drugs and high mortality. The most urgent thing is to find …

01/05/2020

30/04/2020

VA secretary defends use of hydroxychloroquine, clarifies an analysis led to substantial media misinformation

The records review reported outcomes where hydroxychloroquine alone was provided to our sickest COVID-19 patients. The Veterans who received hydroxychloroquine were at highest risk prior …

30/04/2020

27/04/2020

Hydroxychloroquine application is associated with a decreased mortality in critically ill patients with COVID-19

Source: MedRxiv Importance: Coronavirus disease 2019 (COVID-19) is a pandemic with no specific drugs and high mortality. The most urgent thing is to find effective …

27/04/2020

24/04/2020

Iran: Covid-19 Study, a comprehensive investigation from exposure to treatment outcomes – HCQ a treatment option

Source: medRxiv  View ORCID Profile Mohammad Ali Ashraf,  Nasim Shokouhi,  Elham Shirali, Fateme Davari-tanha, Omeed Memar,   View ORCID Profile Alireza Kamalipour,  Ayein Azarnoush,  Avin Mabadi,  Adele Ossareh,  Milad Sanginabadi,  Talat Mokhtari Azad,  Leila Aghaghazvini,  Sara Ghaderkhani,  Tahereh Poordast,  Alieh Pourdast,  Pershang  Nazemi …

24/04/2020

24/04/2020

Official: Kingdom of Bahrain’s, Ministry of Health receives hydroxychloroquine for COVID-19 treatment

In an official statement, Bahrain’s, Ministry of health said: Bahrain has received a shipment of Hydroxychloroquine, following the export approval issued by the government of …

24/04/2020

23/04/2020

Brazil allows use of chloroquine in patients with mild Covid-19 symptoms

The Federal Council of Medicine ( CFM ) authorized the use of chloroquine and hydroxychloroquine in patients infected with Covid-19 , a disease caused by the new coronavirus, showing mild symptoms. According to the …

23/04/2020

21/04/2020

DOJ clears U.S. drug companies to distribute hydroxychloroquine to coronavirus patients

The U.S. Department of Justice on Monday cited “extreme urgency” in clearing U.S. pharmaceutical distributors from legal hurdles in order to provide the controversial anti-malaria …

21/04/2020

21/04/2020

Countries which Primarily Use Antimalarial Drugs As COVID-19 Treatment See Slower Dynamic of Daily Deaths

This study focuses on anti-malarial drugs like hydroxychloroquine, which have been seen as the most used treatment for COVID-19

21/04/2020

17/04/2020

New Brazilian Study Shows Telemedicine & Hydroxychloroquine Reduce Need for Hospitalization

SOURCE: Covexit The advanced copy of a new study, by Rodrigo Barbosa Esper M.D., Ph.D. and collaborators has just been circulated. The study analyzes the …

17/04/2020

17/04/2020

Russia officially approves malaria drug to treat coronavirus.

The Russian government has authorized hospitals to treat coronavirus patients with the untested malaria drug hydroxychloroquine. Thursday’s decree instructs Russia’s national medical cardiology research center to distribute …

17/04/2020

14/04/2020

‘Going on offense’: South Dakota implements first statewide hydroxychloroquine trial in fight against coronavirus

Source: Washington Examiner Watch the excerpt: South Dakota will be the first U.S. state to hold a statewide trial for hydroxychloroquine as a possible treatment of the …

14/04/2020

11/04/2020

Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study

Source: Science Direct PhilippeGautretab1Jean-ChristopheLagierac1PhilippeParolaabVan ThuanHoangabdLineMeddebaJacquesSevestreaMorganeMailheaBarbaraDoudieraCamilleAubryaSophieAmraneaPisethSengaMarieHocquartaCaroleEldinabJulieFinanceeVera EstevesVieiraaHervé TissotTissot-DupontacStéphaneHonoréfgAndreasSteinacMatthieuMillionacPhilippeColsonacBernardLa ScolaacVéroniqueVeithAlexisJacquieriJean-ClaudeDeharojMichelDrancourtacPierre EdouardFournierabJean-MarcRolainacPhilippeBrouquiacDidierRaoultac aIHU-Méditerranée Infection, Marseille, France bAix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France cAix Marseille Univ, …

11/04/2020

06/04/2020

Australian TGA makes amendments to the new restrictions on prescribing hydroxychloroquine for COVID-19

On 24 March 2020, new restrictions came into effect limiting the health practitioners who could initiate therapy with hydroxychloroquine. These were introduced following reports of …

06/04/2020

02/04/2020

Hydroxychloroquine: Australian government waives regulatory requirements for drug

The Morrison government has waived therapeutic goods registration requirements for anti-malarial drugs to prepare for their urgent importation to Australia. On Thursday, hydroxychloroquine and chloroquine …

02/04/2020

30/03/2020

FDA says hydroxychloroquine and chloroquine can be used to treat Coronavirus

The U.S. Food and Drug Administration (FDA) has approved the use of two anti-malaria drugs to treat patients infected by the new coronavirus. On Sunday, the …

30/03/2020

27/03/2020

Russian Health Ministry includes hydrochloroquine in official interim treatments for covid-19

The Russian Health Ministry has provided Version 4 (27/03/2020) interim recommendations for the treatment of COVID-19, which includes their intended dosage and timeline of use. …

27/03/2020

24/03/2020

Australian TGA apply new restrictions on prescribing hydroxychloroquine for COVID-19

In recent days there has been considerable focus on the potential for hydroxychloroquine and the similar compound chloroquine (which is not marketed in Australia) to …

24/03/2020

22/03/2020

China: Wuhan clinical trial, use of HCQ significantly shortens TTCR and promotes absorption of pneumonia

Source medRxiv Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial Zhaowei Chen,  View ORCID ProfileJijia Hu, Zongwei Zhang, Shan Jiang, Shoumeng Han, Dandan Yan, Ruhong Zhuang, Ben Hu,  View ORCID ProfileZhan Zhangdoi: https://doi.org/10.1101/2020.03.22.20040758This article is a preprint and …

22/03/2020

22/03/2020

Jordan authorises use of hydroxychloroquine to treat COVID-19

As leading doctors warn of widespread infection in Jordan, hospitals can now use malaria drug for serious conditions. Jordan’s Food and Drug Administration (FDA) authorised …

22/03/2020

12/03/2020

WHO declares COVID-19 a pandemic

At the WHO’s media briefing on COVID-19, the Director-General’s opening remarks included: “WHO has been assessing this outbreak around the clock and we are deeply …

12/03/2020

02/03/2020

Moscow doctors offered to test a drug for coronavirus on themselves as prophylaxis.

Doctors of subordinate Moscow medical institutions are invited to participate in the study of the drug for the prevention of COVID-19. A medicine called hydroxychloroquine is …

02/03/2020

08/05/2018

Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review

Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious diseases.

08/05/2018

23/11/2017

Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents

Scientific evidence also supports the use of CQ and HCQ in the treatment of cancer.

23/11/2017

15/07/2014

Chloroquine and hydroxychloroquine for cancer therapy

Here, we summarize the results or design of clinical studies recently completed or initiated to evaluate the therapeutic activity of chloroquine derivatives in cancer patients.

15/07/2014

11/09/2011

Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy–treated immunologic nonresponders

HCQ reduces lipopolysaccharide/TLR-mediated immune activation; this compound could be a useful immunomodulant in HIV-infected patients.

11/09/2011

04/11/2010

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

Source: PLOS Pathogens Author: Aartjan J. W. te Velthuis,Sjoerd H. E. van den Worm,Amy C. Sims,Ralph S. Baric,Eric J. Snijder ,Martijn J. van Hemert  Abstract Increasing …

04/11/2010

19/11/2003

Effects of chloroquine on viral infections: an old drug against today’s diseases

The anti-HIV effect of chloroquine/hydroxychloroquine is modest by itself but is additive or synergistic when combined with selected antiretrovirals.

19/11/2003